I have been involved continuously in basic cellular and molecular transplant immunology for 30 years. My basic research has always focused on T cell immunobiology, and for more than 20 years has also focused on issues of migration, trafficking, secondary lymphoid organ structure and function, and lymphatic structure and function, and how these processes and structures influence T cell immunity and T cell tolerance in models of transplantation. I have also maintained an active clinical practice in solid organ transplantation and am thus constantly exposed to the problems of patients and their immune systems, including cellular and humoral rejection, opportunistic infections, chronic viral disease, autoimmune organ failure, and immunosuppression medication side effects. I have had over 60 trainees in my lab, am actively involved in teaching and mentoring, and have served on T32 faculty.