Donor liver shortage has always been the main obstacle limiting the development of liver transplantation. Split liver transplantation and domino liver transplantation can alleviate the problem of donor liver shortage and shorten the waiting time of recipients, and have been implemented in many transplant centers. However, domino liver transplantation with split liver transplantation is rarely reported at home and abroad [1,2]. This paper reports a case of cadaver donor liver split liver transplantation (right half liver) and a case of domino liver transplantation (domino liver). Patient 1 was diagnosed with hepatitis B cirrhosis (decompensated stage) and received split liver transplantation (right half liver). Patient 2 was diagnosed with familial hypercholesterolemia and underwent split liver transplantation (left half liver). Patient 3 was diagnosed with liver malignancies and hepatitis B cirrhosis. The diseased liver of patient 2 was implanted as a domino donor liver to complete domino liver transplantation, thus realizing a cadaver donor liver. Meanwhile, 3 cases of liver transplantation were completed, and all patients recovered smoothly after surgery.