Kaposi-Juliusberg’s syndrome is a rare disease caused by Herpes simplex virus. It isa severe and disseminated skin infection with general signs. Here reporteda rare case of Kaposi-Juliusberg’s syndrome in a kidney transplant patient.This is a case about a 66-year-old male patient. He has a history of hypertension, chronic kidney disease diagnosed in 2001. He reached the end stage of CKDin 2002. He received a living kidney transplant in 2004 from an unrelated living donor. The complications occurring after RT were recurrent urinary tract infections and diabetes. He underwent endoscopic resection of a prostate adenoma in2010 complicated by urethral stenosis.This was treated by recurrent internal urethrotomy due to the persistence of the stenosis after each intervention.Ten days after the 4th internal urethrotomy, the patient was admitted to Sahloul university hospital with fever and dysuria. He presentedpollakiuria and macroscopic hematuria. On physical examination: he had a temperature of 39°C, a heart rate of 110 beats/min and a blood pressure of 120/70 mmHg. No heart murmur or other signs of endocarditis were present. Laboratory results showed a biological inflammatory syndrome (white blood cells at 32000/mm3 and CRP at 370mg/L), Creatinine rose at 50 mg/l. The Blood cultures were positive for Klebsiella Pneumoniae.The diagnosis retained was urinary tract infection complicated by sepsis. He was treated by ertapenem intravenously. Five days after the end of the antibiotic therapy, the patient presented a vesiculo-necrotic eruption with an umbilical varioliform aspect. This affected the face,and especially peri-orificial sites, and the trunk. It has a herpetic appearance with erosive mucosal involvement. He complained also of painful mouth and conjunctiva. He had a temperature at 37 ° C, Blood Pressure of 160/90 mmHg. The cardiac auscultation was normal and the Lung auscultation revealed crackling rales at both lung bases. The abdomen examination was normal.To biology data showed: Urea: 38 mmol/L, creatinine: 52.8 mg/L, CRP 111 mg/L, Proteinuria: 0.56 g/d.The laboratory results included a Hemoglobin of 6 g/dl. The Ciclosporin T0/T2 residual levels were: 68/165 ng/ml. The cytobacteriological urine exam concluded to a rate of leukocyturia at 800/mm3, of hematuria at < 1/ mm3 and a negative culture. The clinical presentation was very suggestive of Kaposi Juliusberg’s syndrome. Therefore a HSV-1 PCR was performed. It was positive at 4300 copies/ml. The diagnosis of Kaposi Juliusberg’s syndrome was retained. The patient was treated by: Acyclovir by intravenous infusion. This was combined withlocal disinfection of the lesions and anti-staphylococcal antibiotic therapy. The ophthalmologic examination for herpetic keratitis was negative. The evolution was marked by improvement of the skin lesions by two weeks of treatment. CRP decreased to 61 mg/land serum creatinine was stable at 38.4 mg/L. After 14 days of antiviral treatment, HSV-1 PCR became negative.