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Xenotransplantation 1

Tuesday September 24, 2024 - 10:40 to 12:10

Room: Üsküdar 3

327.a Cardiac xenotransplantation in humans: Lessons learned and path forward

Muhammad Mohiuddin, United States

Professor of Surgery
Surgery
University of Maryland School of Medicine

Biography

Muhammad Mansoor Mohiuddin, MD/MBBS, DSc(Hon), FAST Dr. Mohiuddin currently serves as a tenured Professor of Surgery and Director of the cardiac xenotransplantation program at the University of Maryland School of Medicine (UMSOM), Baltimore, MD. Dr Mohiuddin previously served as Chief of Transplantation of the Cardiothoracic Surgery Research Program at the National Heart Lung and Blood Institute / the National Institutes of Health (NIH). He held faculty positions at the University of Pennsylvania, Philadelphia, and Rush University, Chicago. He has been involved in Xenotransplantation Research since 1991 and started xenotransplantation research programs at the NIH, Rush University Chicago, and at UMSOM.. He is Associate Editor for Transplantation and reviews manuscripts for many other journals. He is also the past president Dow Graduate Association of North America. His achievements include several NIH and non-NIH grants during his academic career. He is a member of the executive committee of the Community of Transplant Scientists (COTS) and a member of the advisory council of transplant regenerative medicine of the American Society of Transplantation (AST) Dr. Mohiuddin's career has been a testament to his pioneering spirit in Xenotransplantation. His groundbreaking contributions include demonstrating the most prolonged survival in heterotopic and orthotopic cardiac Xenotransplantation. He devised an immunosuppression regimen that significantly extended the lifespan of cardiac xenografts to nearly three years. His leadership extends to the International Xenotransplantation Association (IXA), where he now serves as President, following four years as Councilor and a liaison to foster productive dialogue between the IXA and the FDA. His extensive publication record includes over 120 papers and more than 150 abstracts, and he has been a sought-after expert speaker on Xenotransplantation on numerous occasions. Dr. Mohiuddin's unwavering dedication to Xenotransplantation culminated in two significant milestones. On January 7, 2022, he achieved the First Genetically Engineered pig-to-human cardiac Xenotransplantation, a feat that marked a new era in the field. He then led the second xenotransplantation procedure in September 2023, further solidifying his position as a leader in the field. Both surgeries were successfully conducted at the University of Maryland Medical Center in Baltimore, Maryland. Besides other awards, Dr Mohiuddin was picked by Nature Journal as one of the “Nature’s 10” in 2022. Ten people who helped shape science in 2022.

Presentations by Muhammad Mohiuddin

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