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P.513 Pregnancy in lung transplant recipients

Graciela Svetliza, Argentina

Professor of Pneumologist
Department of Pneumology- Internal medicine
Hospital Italiano Buenos Aires

Biography

Prof Graciela Svetliza MD
Pneumologyst and Lung Transplant Physician - Hospital Italiano de Buenos Aires University Professor at the UBA (Universidad Buenos Aires) and IUHI (Instituto Universitario Hospital Italiano de Buenos Aires).
Actual director of the advisary lung transplant commission of Sociedad Argentina de Trasplantes

Abstract

Pregnancy in lung transplant recipients

Esteban Wainstein1, Graciela Svetliza1, María Orazi1, Agustín Dietrich2, Micaela Raíces2, David Smith2.

1Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; 2Thoracic Surgery, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

Background: pregnancy after lung transplantation has been shown to be feasible in selected patients. There is considerable risk of adverse outcomes for both the mother and child.
The International Society of Heart and Lung Transplantation (ISHLT) recommends a plan that includes deferring  pregnancy for 2 years after transplantation and ensuring teratogenic medications are stopped. Maternal and fetal risk should be discussed.
We aim to describe our experience with pregnancy after lung transplantation.
Methods: single center retrospective study at a large academic center. Using electronics medical records, we included all pregnancies recorded from January 1st 2000 to December 31 2022. Demographic data was collected. Main results were maternal and fetal complications.
Results: 3 female lung transplant recipients had pregnancies during the study period. Median age at transplantation was 24 years. Type of transplantation was as follows: 1 single lung transplant, 1 double lung transplant, 1 heart-lung transplant.  2 patients had a planned pregnancy with a median transplant to pregnancy interval of 41 months. 1 patient had an unplanned pregnancy with an interval from transplantation of 18 months. The last case resulted in an abortion and progressive graft dysfunction.  The other 2 cases had no maternal adverse effects. Elective cesarean section was performed. Low weight at birth occurred but normal development was achieved.
Conclusion: the small number of cases precludes from making generalizations. In our experience, following ISHLT consensus recommendations was associated with successful pregnancy outcomes.

References:

[1] Lung transplant
[2] Pregnancy
[3] Outcome

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