The field is celebrating the 10th birthday of the first baby born after a successful uterus transplant. Mats Brannstroem, the pioneering surgeon of the Gothenburg team will summarize the 10 successful years of uterus transplantation. Ethical debates are particularly relevant, thus requiring a careful debate of ethical guardrails. Unique in many ways, uterus transplantation is the only planned ‘temporary’ engraftment with unique immunological features in the context of transplantation, immunosuppression and pregnancy.