Cultural safety is increasingly recognized as an essential component of quality and safety in healthcare, in particular when providing care for and working with First Nations and Indigenous peoples. In this session comprising two expert talks and a panel discussion, participants will be introduced to the core concept of cultural safety, learn how it may impact equity of access and outcomes of donation and transplantation for First Nations peoples, and learn how to strengthen research in donation and transplantation involving First Nations peoples. The panel discussion will explore common concerns that may arise for non-Indigenous clinicians and researchers, such as fears about tokenistic inclusion and asking patients whether they identify as Indigenous, and anxiety about “cultural load” placed on Indigenous colleagues. Participants will have the opportunity to explore questions and discuss potential strategies to support cultural safety and inclusion of First Nations peoples in a range of settings.