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P.185 Urological complications following the use of a modified ureteral reimplantation technique in kidney transplantation

Marina M Tabbara, United States

Miami Transplant Institute

Abstract

Urological complications following the use of a modified ureteral reimplantation technique in kidney transplantation

Gaetano Ciancio1,2,3, Marina Tabbara1,2, Javier Gonzalez4, Angel Alvarez1,2, Mahmoud Morsi1,2, Jeffrey Gaynor1,2.

1Miami Transplant Institute, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FL, United States; 2DeWitt Daughtry Family Department of Surgery, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FL, United States; 3Department of Urology, Jackson Memorial Hospital, University of Miami Miller School of Medicine, Miami, FL, United States; 4Department of Urology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Introduction: Despite some advances/refinements in the operative technique of kidney transplantation, urologic complications may still occur post-transplant and are associated with recurring morbidity, repeat hospitalizations, and possibly even graft failure or death.
Method: Since 2014, 707 consecutive recipients of a kidney-alone transplant at our center received the following modified ureteral reimplantation technique: bladder mobilization before the kidney transplant, a post-reperfusion check for ureteral blood flow demarcation, and ureteral trimming. Then, a 3cm oblique cystostomy on the bladder dome, exposing the bladder mucosa with detrusor layer(BMDL), was performed, using a posterior ureteral spatulation of 2cm. The heel and apex of the ureter were anchored to the BMDL at almost full thickness with 6-0polydioxanone suture(PDS). Two stay sutures with 6-0PDS were placed lateral and medial anchored to the BMDL to keep the ureter open. The ureteral anastomosis was performed in a running manner with 6-0PDS, lateral wall first and then medial wall. An anti-reflux tunnel was performed using the remaining detrusor muscle and closed with interrupted sutures of 4-0PDS. There was no initial placement of a ureteral stent. All patients were followed for a minimum of 12mo post-transplant.
Results: The percentage of patients developing a urologic complication during the first 12mo post-transplant was 2.3%(16/707). One patient with an ischemic, necrotic ureter was treated with ureteral reimplantation/stent placement. Another patient experienced a ruptured ureteral anastomosis/bladder which was treated by ureteral reimplantation/bladder closure. Two patients who developed a ureteral leak with ureteral necrosis were treated with ureteral reimplantation/stent placement. Two additional patients who developed a developed a ureteral obstruction/stricture due to fibrous tissue surrounding the ureter were treated with surgical dissection of the fibrous tissue/ureteral reimplantation/stent placement. One patient, who developed two ureteral strictures that were treated by interventional radiology(IR), was finally diagnosed as having multiple kidney stones which were occluding the distal ureter; surgical removal of the kidney stones and ureteral reimplantation was performed.  Another patient developed a ureteral stricture due to malrotation of the transplanted kidney, and two patients experienced grade 4 vesicoureteral reflux. In total, surgical repair with ureteral reimplantation was required in 1.0%(7/707) of patients. Surgical repair was required in 2 additional cases(allograft repositioning in one case; bladder augmentation in one case). The other 7 patients who developed a urologic complication were successfully treated by IR. 
Conclusions: We believe that this modified ureteral reimplantation technique clearly helped in reducing post-transplant urologic complication risk and without the need of initial ureteral stent placement.

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