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Pediatric

Tuesday October 22, 2024 - 18:00 to 19:00

Room: Virtual

V212.3 Living donor versus deceased donor in pediatric liver transplantation: A systemic review

Juwairiya Syed Iqbaluddin, United Arab Emirates

Pediatric Resident
Pediatrics
Al Qassimi hospital for woman and children- emirates health services

Abstract

Living donor versus deceased donor in pediatric liver transplantation: A systemic review

Juwairiya Syed Iqbaluddin1, Saista Amin2.

1General Pediatrics, Al Qassimi Hospital For Woman and Children, Sharjah, United Arab Emirates; 2Pediatric Gastroenterology, Al Qassimi Hospital For Woman and Children, Sharjah, United Arab Emirates

Background: Liver transplantation (LT)  has emerged as a lifesaving modality for many liver diseases in children. The history of paediatric liver transplantation has demonstrated that success depends on multidisciplinary involvement of paediatricians, paediatric transplant hepatologists, transplant surgeons, nurses, transplant coordinators, psychologists and social workers. Furthermore, Deceased donors and living donor liver transplantation (LDLT) can address the organ shortage for paediatric liver transplant candidates.
Aim: The aim of this study is to compare outcomes for paediatric LDLT and deceased donor liver transplantation (DDLT) via systematic review. 
Methods: 
A literature search was undertaken utilising keywords such as 'Pediatric Liver transplant,' 'Living donor liver transplant,' and 'Deceased donor liver transplant' across databases including PubMed, Google Scholar, Science Direct, and Cochrane, to identify relevant research papers and articles published from 2000 to 2024. Total of 50 articles were screened and 10 met the criteria. Inclusion criteria were limited to articles specifically addressing paediatric liver transplants, while exclusion criteria encompassed studies involving adult liver transplants, recipients over 18 years of age, or any studies not relevant to the study's objectives.
Conclusion: Our study indicates that living donor liver transplantation (LDLT) yields superior patient survival rates and fewer postoperative complications compared to deceased donor liver transplantation (DDLT) [2]. Additionally, graft survival rates were found to be higher in the LDLT group compared to DDLT recipients. 
Early implementation of LDLT in paediatric liver transplant recipients is crucial for mitigating waitlist-related morbidity. Delaying liver transplantation in paediatric candidates not only increases mortality rates but also exacerbates growth and cognitive delays in those who eventually undergo transplantation. Transplantation with a shorter waiting period can mitigate developmental impairments by reducing hospitalisation frequency, progressive malnutrition, and growth failure before liver transplantation. This, in turn, leads to improved functional outcomes, particularly in young children. 
Our study calls for the need of further local research on this topic and aims to raise community awareness about the significance of organ donation.

References:

[1] Transplantation
[2] deceased donor
[3] living donor

Presentations by Juwairiya Syed Iqbaluddin

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