Outcome of pregnancy in Kidney donors, comparison between pre and post donation and donor’s healthy sisters at large transplant centre
Nada Alamri1, Zainab AlTurki1, Tariq Ali1, Assad Ullah1, Ahmad Nazmi1, Dieter Broering1, Hassan Aleid1.
1Kidney health Science Center, King Faisal Specialist Hospital, Riyadh, Saudi Arabia
Background: Live kidney donation is the preferred therapy for kidney failure patients. Literature raised concerns regarding high rate of preeclampsia and foetal outcome after kidney donation, we aimed to report the largest study of pregnancy outcome after kidney donation in our centre.
Methods: All female donors were surveyed to get details of pregnancy before and after kidney donation, in addition to get their healthy sisters’ data from their sisters. In addition, kidney donors’ information was obtained from electronical medical records. Donors aged 18-50 years, married were included in the study. Study span between January 2007 till end of June 2018. Study was approved by Office of research affairs at same centre.
Results: We included 344 female donors and 344 health sisters. mean data before donation were as follows; age 31.2 + 7.9 years, creatinine 58.6+ 9 umol/l, BMI 25.9 + 3.9, SBP 109+ 7.7 mmHg, DBP 66.4+ 8.8 mmHg.
826 pregnancies occurred before donation giving 756 ( 91.5%) health babies, 27 preeclampsia events occurred, and 70 total pregnancies were lost due to abortions and still birth. In comparison to 454 pregnancies occurred after donation among 290 donors, giving 412 health birth ( 90.7%) not different than pre-donation health birth rate. Mean age at pregnancy after donation was 30.5 + 5.6 years and mean waiting time after donation was 2.37+ 1.7 years.
344 healthy sisters of the donors were included. No data was available for BP, BMI and Creatinine among the sisters. Mean age of sisters at pregnancy was 23.7+ 5.4 years. 1892 pregnancies occurred among the sisters giving 1740 healthy babies. 35 preeclampsia events occurred and , and 152 total pregnancies were lost due to abortions and still birth. There was no difference in abortions, still birth, preeclampsia, and healthy live birth among the donors pre and post donation and their health sisters. Mean number of pregnancies was 3.7+ 1.8 vs. 5.5 + 2.5 among sisters, P 0.0001 with difference of 1.8+ 1.66.
Conclusion: Among health kidney donors, data showed good pregnancy outcome in comparisons to pre donation pregnancy and their healthy sister data with no increase in abortion, preeclampsia and still birth, giving health births in > 90% of pregnancy. Rate of pregnancy was lower among kidney donors compared to their sisters.
